Dapoxetine sildenafil medicines for premature ejaculation
Premature ejaculation: definition of Dapoxetine sildenafil
We speak of premature ejaculation when a man ejaculates too quickly. But what does too fast mean? What is the standard? In fact, only the estimation of the man and his partner is important : we speak of premature ejaculation if it occurs before one or the other wishes it. More simply, not having premature ejaculation means being able to decide when to ejaculate.
We do not know exactly what causes it, but it is important to understand that premature ejaculation is not a disease . According to recent research, brain neurotransmi
Dapoxetine, the first drug against premature ejaculation
Certain medications have the power to slow down the establishment of the ejaculation reflex . Since April 2013, a first treatment, Dapoxetine sildenafil (marketed under the name PRILIGY ®) has received Marketing Authorization in the treatment of premature ejaculation in men aged 18 to 64 years. According to a Dutch study, this psychotropic can multiply by about 3 the time between penetration and ejaculation , after a treatment period of twelve weeks . 1
However, the placebo had the same effects as the Dapoxetine sildenafil itself. Note that it also causes very annoying side effects: headaches, nausea, diarrhea, dizziness… Reservations have therefore been expressed about it: ” its limited effectiveness was not considered sufficient to justify its effects undesirable effects”, notes an article in the Revue Prescrire in 2013. 2 It has ” an unfavorable benefit-risk balance due to moderate efficacy and numerous and sometimes serious adverse effects” , note the researchers. 2 Not to mention that Dapoxetine sildenafil exposes to many drug interactions : vasodilators, antidepressants, IRS or monoamine oxidase inhibitors (MAOIs)…
“ European Union health authorities would have been better off denying marketing authorization (MA) for dapoxetine usa, dapoxetine uk and dapoxetine australia in premature ejaculation, as the Food and Drug Administration (FDA) did. American ,” they conclude. 2
Local treatment of premature ejaculation
Since 2018, Stud 5000, a fixed combination of local anesthetics ( lidocaine ) has been marketed as a spray to be sprayed on the glans. These two anesthetics block the transmission of nerve impulses in the glans penis and thus reduce its sensitivity. The effectiveness of Stud 5000 has been proven in 2 trials involving 556 men bothered by an ejaculation delay considered too short. 3 After 3 months, 72% of men and 77% of partners taking this treatment declared that they were satisfied with their sexual relations by Dapoxetine sildenafil , compared to 24% and 3 5% who took a placebo.3 Be careful, however: Stud 5000 causes significant side effects .
They are mainly local and present in men and women :
- erectile dysfunction;
- Decreased sensitivity;
- Redness and failure of ejaculation in men;
- Vulvovaginal burning sensation;
- Vaginal pain;
- Decreased sensitivity;
Note : in couples trying to have a child, there is a risk of reduced sperm motility. Thus, it is better to avoid this treatment, or wash the glans before intercourse. In pregnant women , the use of a condom is recommended (avoiding those based on polyurethane, which are weakened by these local anesthetics).
Note : reservations have been made regarding the effectiveness of the therapies. In 2011, the Cochrane review assessed the effectiveness of psychosocial interventions for PE and identified 4 trials involving 253 patients with PE. 5 Result: “Overall, the evidence is inconsistent and weak for the effectiveness of psychological interventions for the treatment of premature ejaculation” . Randomized trials with larger group samples are still needed.